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Pathol Res Pract. 2019 Jan 30. pii: S0344-0338(18)31655-8.WB;Human.PubMed:30777616[IF=1.44]Zhou F et al.Salidroside protected against MPP+‐induced Parkinson\'s disease in PC12 cells by inhibiting inflammation, oxidative stress and cell apoptosis.(2018) Biotechnol Appl Biochem.WB;Rat .PubMed:30548933[IF=1.438]Jiang JY et al. Effects of estradiol and progesterone on secretion of epidermal growth factor and insulin-like growth factor-1 in cultured yak endometrial epithelial cells. Tissue Cell. 2018 Jun;52:28-34.WB;Yak.PubMed:29857825[IF=1.422]Ran M et al. miR-26a suppresses autophagy in swine Sertoli cells by targeting ULK2.Reprod Domest Anim. 2018 Aug;53(4):864-871. WB;Shaziling boar.PubMed:29761550[IF=1.42]Karaboga, İhsan, Selim Demirtas, and Turan Karaca. \"Investigation of the relationship between the Th17/IL-23 pathway and innate-adaptive immune system in TNBS-induced colitis in rats.\" Iranian Journal of Basic Medical Sciences 20.8 (2017): 870-879.WB;Rat.PubMed:29085578[IF=1.41]Wu and Huang Synergistic enhancement of matrix metalloproteinase-9 expression and pro-inflammatory cytokines by influenza virus infection and oxidized-LDL treatment in human endothelial cells. (2017) Exp.Ther.Med. 14:4579-4585WB;human.PubMed:29104665[IF=1.41]Song et al. Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions. (2018) Exp.Ther.Med. 15:5251-5260WB;Rat.PubMed:29904409[IF=1.396]Su N et al. Wnt/β-catenin deficiency inhibits multiple myeloma cell growth via AMPK/mTOR signaling. Int J Clin Exp Med. 2018;11(6):5657-5665.WB;Human.PubMed:ISSN:1940-5901/IJCEM0064342.[IF=1.39]Chen et al. Wnt4 overexpression promotes thymoma development through a JNK-mediated planar cell polarity-like pathway. (2018) Oncol.Lett. 15:83-90WB;Human.PubMed:29387212[IF=1.39]Cao et al. MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7. (2018) Oncol.Lett. 15:453-458WB;Human.PubMed:29422961[IF=1.39]Chen, Yuan, et al. \"Wnt4 overexpression promotes thymoma development through a JNK‑mediated planar cell polarity‑like pathway.\" Oncology Letters.WB;Human.PubMed:29387212[IF=1.39]Chang et al. MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma. (2015) Oncol.Let. 10:2781-2786WB;Human.PubMed:26722242[IF=1.39]Chang et al. MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma. (2015) Oncol.Let. 10:2781-2786WB;Human.PubMed:26722242[IF=1.38]Huang, Chen, et al. \"Expression, purification, and functional characterization of recombinant PTD-SARA.\" Acta biochimica et biophysica Sinica 43.2 (2011): 110-117.WB;PubMed:21266541[IF=1.37]Zhu et al. Expression of serotonin receptors in the colonic tissue of chronic diarrhea rats. (2016) Saudi.J.Gastroentero. 22:234-9WB;Rat.PubMed:27184643[IF=1.344]Gu et al. Angiopoietin-1 and Angiopoietin-2 Expression Imbalance Influence in Early Period After Subarachnoid Hemorrhage. (2016) Int.Neurourol.. 20:288-295WB;Rat.PubMed:28043115[IF=1.311]Nie Y et al. KH-type splicing regulatory protein is regulated by nuclear factor-κB signaling to mediate innate immunity in Caco-2 cells infected by Salmonella enteritidis.Folia Microbiol (Praha). 2018 Nov;63(6):669-676. WB;Human.PubMed:29728998[IF=1.31]Wang, Chunqiang, Wei Ma, and Yuhong Su. \"NF-??B Pathway Contributes to Cadmium-Induced Apoptosis of Porcine Granulosa Cells.\"Biological trace element research (2013): 1-8.cWB;Pig.PubMed:23575899[IF=1.28]Wu, Xue-Mei, et al. \"Inhibition of connexin 36 decreases seizure activity in the Kainic acid-induced rat model of epilepsy.\" Int J Clin Exp Med 9.2 (2016): 2277-2284.WB;Rat.PubMed:0Human,Mouse,Rat,(predicted: Chicken,Dog,Pig,Rabbit,Sheep,Bee,Fish,Guinea Pig,Hamster,Cat,mt,op)WB=1:5000-20000ELISA=1:5000-20000IHC-P=1:500-1000Flow-Cyt=1μg/TestICC=1:100（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.Loading ControlThis gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008].Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.Subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2.Subcellular Location:Cytoplasm. cytoskeleton.Tissue Specificity:Ubiquitously expressed in all eukaryotic cells.Post-translational modifications:ISGylated.Oxidation of Met-44 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.DISEASE:Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.Similarity:Belongs to the actin family.SWISS:P60709, P60709Gene ID:60, 60Database links: Entrez Gene: 396526 Chicken Entrez Gene: 60 Human Entrez Gene: 11461 Mouse Entrez Gene: 100009272 Rabbit Entrez Gene: 81822 Rat Omim: 102630 Human SwissProt: P60706 Chicken SwissProt: P60712 Cow SwissProt: P60708 Horse SwissProt: P60709 Human SwissProt: P60710 Mouse SwissProt: P29751 Rabbit SwissProt: P60711 Rat SwissProt: P60713 Sheep Unigene: 520640 Human Unigene: 708120 Human Unigene: 727576 Human Unigene: 328431 Mouse Unigene: 391967 Mouse Unigene: 94978 RatImportant Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.内参抗体 β-Actin是横纹肌肌纤维中的一种主要蛋白质成分，也是肌肉细丝及细胞骨架微丝的主要成分。具有收缩功能，分布广泛，具有高度保守性，在细胞中的表达相对稳定，因此常被用作校正系统的内参。β-Actin分子量为42 kDa，此抗体主要用于标记平滑肌及其来源的肿瘤。我公司开发的β-Actin抗体已被国内外广大科研工作者使用，被称谓：质量信得过产品. Lane1: Anti-beta-Actin (bs-0061R) at 1/500 dilutionLane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilutionLane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilutionLane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDLane1: Anti-beta-Actin (bs-0061R) at 1/500 dilutionLane2: Anti-beta-Actin (bs-0061R) at 1/1000 dilutionLane3: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionLane4: Anti-beta-Actin (bs-0061R) at 1/4000 dilutionLane5: Anti-beta-Actin (bs-0061R) at 1/5000 dilutionLane6: Anti-beta-Actin (bs-0061R) at 1/8000 dilutionLane7: Anti-beta-Actin (bs-0061R) at 1/10000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDLane3: A431 Cell Lysate at 25 ugPrimary: Anti- beta-Actin (bs-0061R) at 1/1000 and 1/5000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42kDObserved band size: 42 kDSample: Lung lysate at 30ug;Primary: Anti-beta-actin (bs-0061R) at 1:1000 dilution Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1:3000 dilutionPredicted band size : 42kDObserved band size : 42kDAnti-beta-Actin (bs-0061R) at 1/2000~1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDAnti-beta-Actin (bs-0061R) at 1/1000~1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDAnti-beta-Actin (bs-0061R) at 1/1000~1/20000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDTM4 (Human) Cell Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDEC9706 (Human) Cell Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDA431 (Human) Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDtrachea (Mouse) Lysate at 40 ugPrimary: Anti-beta-Actin (bs-0061R) at 1/2000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 42 kDTissue/cell: human cervical carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Beta-actin Polyclonal Antibody, Unconjugated(bs-0061R) 1:1500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) stainingTissue/cell: Hela cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG-FITC antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.MCF7 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (beta-Actin) polyclonal Antibody, Unconjugated (bs-0061R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.Blank control: NIH/3T3.Primary Antibody (green line): Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R) Dilution: 1μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF488Dilution: 1μg /test. ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.Blank control:Mouse spleen.Primary Antibody (green line): Rabbit Anti-beta-Actin (Loading Control) antibody (bs-0061R) Dilution: 2μg /10^6 cells;Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF647Dilution: 1μg /test. ProtocolThe cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.Blank control: RSC96(blue).Primary Antibody: Rabbit Anti-beta-Actin /FITC Conjugated antibody (bs-0061R/FITC), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;Isotype Control Antibody: Rabbit IgG/FITC(orange) ,used under the same conditions.ProtocolThe cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. The cells were washed twice with 1 X PBS. The cells were incubated in 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions followed by the incubated with antibody (bs-0061R/FITC, 1μg /1x10^6 cells) for 30 min on ice. Acquisition of 20,000 events was performed.